Apilast 10 Tablet
Generic : Apremilast 10 mg
Therapeutic : Apremilast 10 mg
Composition :
Apilast 10 Tablet : Each film coated tablet contains Apremilast INN 10 mg.
Description :
Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) enzyme specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels. The specific mechanism by which Apremilast exerts its therapeutic action in psoriatic arthritis and psoriasis patients is not well defined.
Indications :
Apremilast is indicated for the treatment of adult patients with active psoriatic arthritis and moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.
Dosage & Administration :
The recommended initial dosage titration of Apremilast from Day 1 to Day 5 is shown below. Following the 5 day titration, the recommended maintenance dosage is 30 mg twice daily taken orally starting on Day 6. This titration is intended to reduce the gastrointestinal symptoms associated with initial therapy.
Apremilast can be administered without regard to meals.
Dosage Adjustment in Patients with Severe Renal Impairment:
Apremilast dosage should be reduced to 30 mg once daily in patients with severe renal impairment. For initial dosage titration, it is recommended that Apremilast be titrated using only the morning schedule and the evening doses be skipped.
Side Effects :
The most frequently occurring side effects of Apremilast are nausea, diarrhea, depression and headache. Other less frequent side effects are upper respiratory tract infection, vomiting, nasopharyngitis, abdominal pain, hypersensitivity, gastroesophageal reflux disease, dyspepsia, fatigue, decreased appetite, cough, rash & insomnia.
Use in Special Group :
Pregnancy : Pregnancy category C.
Lactation : It is not known whether Apremilast or its metabolites are present in human milk; however Apremilast was detected in milk of lactating mice. Caution should be exercised when Apremilast is administered to a nursing woman.
Pediatric Use : The safety and effectiveness of Apremilast in pediatric patients less than18 years of age have not been established.
Contraindications :
Apremilast is contraindicated in patients with a known hypersensitivity to Apremilast.
Precautions :
Treatment with Apremilast is associated with an increase in adverse reactions of depression. Patients, their caregivers and families should be advised of the need to be alert for the emergence or worsening of depression, suicidal thoughts or other mood changes and if such changes occur to contact their healthcare provider. Prescribers should carefully evaluate the risks and benefits of continuing treatment with Apremilast if such events occur.
Drug Interaction :
Co-administration of strong cytochrome P450 enzyme inducer resulted in a reduction of systemic exposure of Apremilast. Therefore, the use of cytochrome P450 enzyme inducers (e.g., Rifampin, Phenobarbital, Carbamazepine, Phenytoin) with Apremilast is not recommended.
Storage :
Keep away from light, moisture and store below 30o C. Keep out of reach of children.
Commercial Pack :
Apilast 10 Tablet : Each box contains 3 X 10 tablets in blister pack.
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